Anti-Cortisol Binding Globulin/SERPINA6 Antibody Picoband®

About this product

Boster Bio Anti-Cortisol Binding Globulin/SERPINA6 Antibody catalog # PA2230. Tested in IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PA2230

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Corticosteroid-binding globulin (CBG), also known as Serpin A6 is a protein that in humans is encoded by the SERPINA6 gene. It is mapped 14q32.13. This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.

Synonyms

Corticosteroid-binding globulin; CBG; Serpin A6; Transcortin; SERPINA6; CBG

Gene Name

SERPINA6

Gene ID

866

UniProt

P08185

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Cortisol Binding Globulin.

Clonality

Polyclonal

Tissue Specificity

Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.

Applications

IHC, ICC, WB

Field of Research

Cancer, Lipid Metabolism, Metabolism, Signal Transduction

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. .

References & Citations

1. Buss, C., Schuelter, U., Hesse, J., Moser, D., Phillips, D. I., Hellhammer, D., Meyer, J. Haploinsufficiency of the SEPRINA6 gene is associated with severe muscle fatigue: a de novo mutation in corticosteroid-binding globulin deficiency. J. Neural Transm. 114: 563-569, 2007. 2. Torpy, D. J., Bachmann, A. W., Grice, J. E., Fitzgerald, S. P., Phillips, P. J., Whitworth, J. A., Jackson, R. V. Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension. J. Clin. Endocr. Metab. 86: 3692-3700, 2001.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

45141 MW

Observed Molecular Weight

60 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Corticosteroid-binding globulin

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the serpin family.

Protein Name

Corticosteroid-binding globulin

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.