Anti-ACTH/POMC Antibody

About this product

Boster Bio Anti-ACTH/POMC Antibody Picoband® catalog # PB9039. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

PB9039

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus) . Its principal effects are increased production and release of corticosteroids. ACTH stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells, especially in the zona fasciculata of the adrenal glands. This gene can influence steroid hormone secretion by both rapid short-term mechanisms that take place within minutes and slower long-term actions. Besides, ACTH also enhances transcription of mitochondrial genes that encode for subunits of mitochondrial oxidative phosphorylation systems.

Synonyms

Pro-opiomelanocortin; POMC; Corticotropin-lipotropin; NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanotropin alpha; Alpha-MSH; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanotropin beta; Beta-MSH; Beta-endorphin; Met-enkephalin; POMC

Gene Name

POMC

Gene ID

5443

UniProt

P01189

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human ACTH, different from the related mouse and rat sequences by two amino acids.

Clonality

Polyclonal

Tissue Specificity

ACTH and MSH are produced by the pituitary gland.

Applications

IHC

Field of Research

Endocrine System, Energy Metabolism, Growth Factors/Hormones, Hormone Biosynthesis, Metabolic Signaling Pathway, Metabolism, Neurology Process, Neuropeptides, Neuroscience, Neurotransmitter, Pathways and Processes, Signal Transduction, Tumor Biomarkers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

ACTH stimulates the adrenal glands to release cortisol.

References & Citations

1. Dibner, Charna; Schibler, Ueli; Albrecht, Urs (2010) . The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks. Annual Review of Physiology72: 517–549. 2. Hanukoglu I, Feuchtwanger R, Hanukoglu A (November 1990) . Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells. J. Biol. Chem. 265 (33) : 20602–8. 3. Raikhinstein M, Zohar M, Hanukoglu I (February 1994) . cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor. Biochim. Biophys. Acta 1220 (3) : 329–32.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

29424 MW

Observed Molecular Weight

30 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Pro-opiomelanocortin

Subcellular Location

Secreted.

Sequence Similarities

Belongs to the POMC family.

Protein Name

Pro-opiomelanocortin

Isotype

Rabbit IgG

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.