Anti-CD23/FCER2 Antibody Picoband®

About this product

Boster Bio Anti-CD23/FCER2 Antibody Picoband® catalog # PB9051. Tested in ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

PB9051

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD23, also known as Fc epsilon RII, or FcεRII, is the low-affinity receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages. As part of a mapping of multiple probes to specific bands on chromosome 19 by fluorescence in situ hybridization, the FCE2 gene was assigned to 19p13.3. CD23 (FCE2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor.

Synonyms

Low affinity immunoglobulin epsilon Fc receptor; Fc-epsilon-RII; Lymphocyte IgE receptor; CD23; Fcer2; Fcer2a

Gene Name

FCER2

Gene ID

14128

UniProt

P20693

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived mouse CD23 recombinant protein (Position: E50-P331) . Mouse CD23 shares 52% amino acid (aa) sequence identity with human CD23.

Clonality

Polyclonal

Tissue Specificity

Expressed on B-cells.

Applications

ELISA (Cap), Flow Cytometry, IF, IHC, IHC-F, ICC, WB

Field of Research

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Receptors, Stem Cells

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen) .

References & Citations

1. Lichtman AH, Abbas AK (2003) . Cellular and molecular immunology. Philadelphia: Saunders. pp. 324–325. 2. Weskamp, G., Ford, J. W., Sturgill, J., Martin, S., Docherty, A. J. P., Swendeman, S., Broadway, N., Hartmann, D., Saftig, P., Umland, S., Sehara-Fujisawa, A., Black, R. A., Ludwig, A., Becherer, J. D., Conrad, D. H., Blobel, C. P.ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.Nature Immun. 7: 1293-1298, 2006.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

37648 MW

Observed Molecular Weight

49 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Low affinity immunoglobulin epsilon Fc receptor

Subcellular Location

Cell membrane ; Single-pass type II membrane protein . Cell membrane ; Lipid-anchor .

Sequence Similarities

Contains 1 C-type lectin domain.

Protein Name

Low affinity immunoglobulin epsilon Fc receptor

Isotype

Rabbit IgG

Contents

243