Anti-CD30/TNFRSF8 Antibody Picoband®

About this product

Boster Bio Anti-CD30/TNFRSF8 Antibody catalog # RP1029. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Specifications

Catalog number

RP1029

Size / count

100 µg/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Background

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. This gene is mapped to 1p36.22. CD30 is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors. CD30 mast cell activation represents an IgE-independent activation pathway, which is important for understanding cutaneous inflammation associated with mast cells. In addition to those, CD30 is also associated with anaplastic large cell lymphoma.

Synonyms

Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD30; TNFRSF8; CD30, D1S166E

Gene Name

TNFRSF8

Gene ID

943

UniProt

P28908

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human CD30 recombinant protein (Position: T322-K595) . Human CD30 shares 60% and 57% amino acid (aa) sequences identity with mouse and rat CD30, respectively.

Clonality

Polyclonal

Applications

WB

Field of Research

Cancer, Cell Type Markers, Cytokines, Immunology, Innate Immunity, Receptors, TNF Superfamily, Tumor Biomarkers, Tumor Immunology

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B.

References & Citations

1. Fischer, M., Harvima, I. T., Carvalho, R. F. S., Moller, C., Naukkarinen, A., Enblad, G., Nilsson, G. Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J. Clin. Invest. 116: 2748-2756, 2006. 2. Gorczyca W, Tsang P, Liu Z, et al. (February 2003) . CD30-positive T-cell lymphomas co-expressing CD15: an immunohistochemical analysis. Int. J. Oncol. 22 (2) : 319–24. 3. Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL (2005) . [Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]. Zhonghua Bing Li Xue Za Zhi (in Chinese) 34 (11) : 711–5.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

63747 MW

Observed Molecular Weight

110 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Tumor necrosis factor receptor superfamily member 8

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Sequence Similarities

Contains 6 TNFR-Cys repeats.

Protein Name

Tumor necrosis factor receptor superfamily member 8

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.