Anti-Phospho-LAT (Y191) Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Phospho-LAT (Y191) Rabbit Monoclonal Antibody catalog # P01654. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

P01654

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Phospho Site

Y191

Synonyms

Linker for activation of T-cells family member 1;36 kDa phospho-tyrosine adapter protein; pp36; p36-38; LAT

Gene Name

LAT

Gene ID

27040

UniProt

O43561

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Phospho-LAT (Y191)

Clonality

Monoclonal

Clone

Clone: AOH-12

Tissue Specificity

Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level) . .

Applications

WB, IHC, ICC, IF, IP

Field of Research

Adapters, Adaptive Immunity, G Protein Signaling, Immunology, Non-CD, Ras Family, Signal Transduction, Signaling Pathway, Small G Proteins, T Cells, Transmembrane

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Required for TCR (T-cell antigen receptor) - and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III) -mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor) -mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

27930 MW

Observed Molecular Weight

156 kDa

Gene Name Synonym

Linker for activation of T-cells family member 1

Subcellular Location

Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.