Anti-Phospho-GSK3 (alpha + beta) (Y216 + Y279) GSK3A Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Phospho-GSK3 (alpha + beta) (Y216 + Y279) GSK3A Rabbit Monoclonal Antibody catalog # P03152-1. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

P03152-1

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Phospho Site

Y216, Y279

Synonyms

Glycogen synthase kinase-3 alpha; GSK-3 alpha;2.7.11.26; Serine/threonine-protein kinase GSK3A;2.7.11.1; GSK3A

Gene Name

GSK3A

Gene ID

2931

UniProt

P49840

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Phospho-GSK3 (alpha + beta) (Y216 + Y279)

Clonality

Monoclonal

Clone

Clone: IFB-7

Tissue Specificity

Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. .

Applications

WB, IHC, ICC, IF, IP

Field of Research

Apoptosis, Cancer, Cell Biology, G Protein Signaling, Host-Virus Interaction, Interspecies Interaction, Intracellular, Kinases, Microbiology, Neural Signal Transduction, Neurology Process, Neuroscience, Protein Phosphorylation, Ras Family, Ser/Thr Kinases, Serine/Threonine Kinases, Signal Transduction, Signaling Pathway, Small G Proteins

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

50981 MW

Observed Molecular Weight

47, 51 kDa

Gene Name Synonym

Glycogen synthase kinase-3 alpha

Subcellular Location

Cytoplasm .

Protein Name

Glutamate receptor 1

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.