Anti-p21 CDKN1A Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-p21 CDKN1A Rabbit Monoclonal Antibody catalog # M00145-3. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human.

Specifications

Catalog number

M00145-3

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21; CDKN1A; CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1

Gene Name

CDKN1A

Gene ID

1026

UniProt

P38936

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human p21

Clonality

Monoclonal

Clone

Clone: ACG-3

Tissue Specificity

Expressed in all adult tissues, with 5-fold lower levels observed in the brain.

Applications

WB, IHC, ICC, IF, IP

Field of Research

Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Chromatin Binding Proteins, Co-Activators/Co-Repressors, DNA/RNA Binding, Domain Families, Epigenetics and Nuclear Signaling, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription, Zinc Finger

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

18119 MW

Observed Molecular Weight

95 kDa

Gene Name Synonym

Cyclin-dependent kinase inhibitor 1

Subcellular Location

Cytoplasm. Nucleus.

Protein Name

P2X purinoceptor 1

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.