Anti-RIP RIPK1 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-RIP RIPK1 Rabbit Monoclonal Antibody catalog # M00141. Tested in WB, Flow Cytometry applications. This antibody reacts with Human.

Specifications

Catalog number

M00141

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Receptor-interacting serine/threonine-protein kinase 1;2.7.11.1; Cell death protein RIP; Receptor-interacting protein 1; RIP-1; Serine/threonine-protein kinase RIP; RIPK1; RIP, RIP1

Gene Name

RIPK1

Gene ID

8737

UniProt

Q13546

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human RIP

Clonality

Monoclonal

Clone

Clone: IGF-18

Tissue Specificity

Produced by normal alveolar macrophages and granulocytes.

Applications

WB, Flow Cytometry

Field of Research

Apoptosis, Cancer, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Kinases, Protein Phosphorylation, Receptors, Ser/Thr Kinases, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

75931 MW

Observed Molecular Weight

76 kDa

Gene Name Synonym

Receptor-interacting serine/threonine-protein kinase 1

Subcellular Location

Cytoplasm. Cell membrane .

Protein Name

P2X purinoceptor 1

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.