Anti-DR5 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-DR5 Rabbit Monoclonal Antibody catalog # M00410. Tested in WB, IP, Flow Cytometry applications. This antibody reacts with Human.

Specifications

Catalog number

M00410

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Tumor necrosis factor receptor superfamily member 10B; Death receptor 5; TNF-related apoptosis-inducing ligand receptor 2; TRAIL receptor 2; TRAIL-R2; CD262; TNFRSF10B; DR5, KILLER, TRAILR2, TRICK2, ZTNFR9; UNQ160/PRO186

Gene Name

TNFRSF10B

Gene ID

8795

UniProt

O14763

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human DR5

Clonality

Monoclonal

Clone

Clone: ABFC-20

Tissue Specificity

Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.

Applications

WB, IP, Flow Cytometry

Field of Research

Apoptosis, Cancer, Cell Biology, Growth Factors, Growth Factors/Hormones, Receptors, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

47878 MW

Observed Molecular Weight

52 kDa

Gene Name Synonym

Tumor necrosis factor receptor superfamily member 10B

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.