Anti-PDX1/Ipf1 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-PDX1/Ipf1 Rabbit Monoclonal Antibody catalog # M00491. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Specifications

Catalog number

M00491

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Pancreas/duodenum homeobox protein 1; PDX-1; Glucose-sensitive factor; GSF; Insulin promoter factor 1; IPF-1; Insulin upstream factor 1; IUF-1; Islet/duodenum homeobox-1; IDX-1; Somatostatin-transactivating factor 1; STF-1; PDX1; IPF1, STF1

Gene Name

PDX1

Gene ID

3651

UniProt

P52945

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human PDX1

Clonality

Monoclonal

Clone

Clone: AEC-16

Tissue Specificity

Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells) .

Applications

WB, IHC, ICC, IF

Field of Research

Atherosclerosis, Cancer, Cardiovascular, Developmental Biology, Diabetes, Diabetes-associated, Epigenetics and Nuclear Signaling, Growth Factors, Growth Factors/Hormones, Lineage Markers, Lineage Specification, Metabolism, Organogenesis, Signal Transduction, Stem Cells, Transcription

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

30771 MW

Observed Molecular Weight

42 kDa

Gene Name Synonym

Pancreas/duodenum homeobox protein 1

Subcellular Location

Nucleus. Cytoplasm, cytosol .

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.