Anti-CD46 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-CD46 Rabbit Monoclonal Antibody catalog # M00377-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Specifications

Catalog number

M00377-1

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Membrane cofactor protein; TLX; Trophoblast leukocyte common antigen; CD46; CD46; MCP, MIC10

Gene Name

CD46

Gene ID

4179

UniProt

P15529

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human CD46

Clonality

Monoclonal

Clone

Clone: AEI-3

Tissue Specificity

Expressed by all cells except erythrocytes.

Applications

WB, IHC, ICC, IF

Field of Research

Cell Type Markers, Complement, Immunology, Innate Immunity

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and ly induce an immunosuppressive phenotype in T-cells by binding to CD46. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

43747 MW

Observed Molecular Weight

125 kDa

Gene Name Synonym

Membrane cofactor protein

Subcellular Location

Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane ; Single- pass type I membrane protein . Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.