Anti-IRF7 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-IRF7 Rabbit Monoclonal Antibody catalog # M00115. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M00115

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Interferon regulatory factor 7; IRF-7; IRF7

Gene Name

IRF7

Gene ID

3665

UniProt

Q92985

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human IRF7

Clonality

Monoclonal

Clone

Clone: FAH-9

Tissue Specificity

Expressed predominantly in spleen, thymus and peripheral blood leukocytes.

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

Antiviral Signaling, Cytokines, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Host-Virus Interaction, Immune System Diseases, Immunology, Innate Immunity, Interferons, Interspecies Interaction, Microbiology, Pol II Transcription, Polymerase Associated Factors, TLR Signaling, Transcription

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Key transcriptional regulator of type I interferon (IFN) -dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either ly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

54278 MW

Observed Molecular Weight

31 kDa

Gene Name Synonym

Interferon regulatory factor 7

Subcellular Location

Nucleus. Cytoplasm. The phosphorylated and active form accumulates selectively in the nucleus.

Protein Name

P2X purinoceptor 1

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.