Anti-RAGE Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-RAGE Rabbit Monoclonal Antibody catalog # M03438. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M03438

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; AGER; RAGE

Gene Name

AGER

Gene ID

177

UniProt

Q15109

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human RAGE

Clonality

Monoclonal

Clone

Clone: AOBF-1

Tissue Specificity

Endothelial cells.

Applications

WB

Field of Research

Alzheimer's Disease, Atherosclerosis, Cardiovascular, Diabetes-associated, Neurodegenerative Disease, Neurology Process, Neuroscience, Sensory System, Vascular Inflammation, Visual System

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Mediates interactions of advanced glycosylation end products (AGE) . These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity) . Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

42803 MW

Observed Molecular Weight

150 kDa

Gene Name Synonym

Advanced glycosylation end product-specific receptor

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.