Anti-HDAC2/Histone Deacetylase 2 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-HDAC2/Histone Deacetylase 2 Rabbit Monoclonal Antibody catalog # M00325-1. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M00325-1

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Histone deacetylase 2; HD2;3.5.1.98; HDAC2

Gene Name

HDAC2

Gene ID

3066

UniProt

Q92769

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human HDAC2

Clonality

Monoclonal

Clone

Clone: AAE-8

Tissue Specificity

Widely expressed; lower levels in brain and lung.

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

Acetylation, Cardiovascular, Chromatin Modifying Enzymes, Class I, Epigenetics and Nuclear Signaling, Hypertrophy, Signaling Pathways, Stem Cells

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

55364 MW

Observed Molecular Weight

47 kDa

Gene Name Synonym

Histone deacetylase 2

Subcellular Location

Nucleus . Cytoplasm .

Protein Name

P2X purinoceptor 1

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.