Anti-MMP14/Mt1 Mmp Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-MMP14/Mt1 Mmp Rabbit Monoclonal Antibody catalog # M00656. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M00656

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Matrix metalloproteinase-14; MMP-14;3.4.24.80; MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP; MMP14

Gene Name

MMP14

Gene ID

4323

UniProt

P50281

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human MMP14

Clonality

Monoclonal

Clone

Clone: BFD-13

Tissue Specificity

Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. .

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metabolism, Metabolism Processes, Metalloprotease, Pathways and Processes, Proteolysis/Ubiquitin, Proteolytic Enzymes, Response To Hypoxia, Signal Transduction, Tumor Biomarkers

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro- MMP2. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

66 kDa

Observed Molecular Weight

55 kDa

Gene Name Synonym

Matrix metalloproteinase-14

Subcellular Location

Membrane ; Single-pass type I membrane protein . Melanosome. Cytoplasm. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.