Anti-MERTK/Mer Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-MERTK/Mer Rabbit Monoclonal Antibody catalog # M00489. Tested in WB, IHC, IP applications. This antibody reacts with Human.

Specifications

Catalog number

M00489

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Tyrosine-protein kinase Mer;2.7.10.1; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; MERTK; MER

Gene Name

MERTK

Gene ID

10461

UniProt

Q12866

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human MERTK

Clonality

Monoclonal

Clone

Clone: COI-13

Tissue Specificity

Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.

Applications

WB, IHC, IP

Field of Research

Intracellular Signaling, Kinases, Neuroscience, Neurotransmission, Protein Phosphorylation, Receptor Tyrosine Kinases, Sensory System, Signal Transduction, Tyrosine Kinases, Visual System

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis) . Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs) -mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

110249 MW

Observed Molecular Weight

52 kDa

Gene Name Synonym

Tyrosine-protein kinase Mer

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.