Anti-SIRT6 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-SIRT6 Rabbit Monoclonal Antibody catalog # M00611. Tested in WB application. This antibody reacts with Human.

Specifications

Catalog number

M00611

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

NAD-dependent protein deacetylase sirtuin-6;3.5.1.-; Regulatory protein SIR2 homolog 6; SIR2-like protein 6; SIRT6; SIR2L6

Gene Name

SIRT6

Gene ID

51548

UniProt

Q8N6T7

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human SIRT6

Clonality

Monoclonal

Clone

Clone: HBA-19

Tissue Specificity

Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines. .

Applications

WB

Field of Research

Acetylation, Apoptosis, Atherosclerosis, Cancer, Cardiovascular,2339, Chromatin Modifying Enzymes, Diabetes-associated, Epigenetics and Nuclear Signaling, Metabolism, NFKB Pathway, Nuclear Signaling Pathways, Obesity, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity) . Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD (+) in the absence of acetylated substrate. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

39119 MW

Observed Molecular Weight

32-42 kDa, 65 kDa, 75 kDa

Gene Name Synonym

NAD-dependent protein deacetylase sirtuin-6

Subcellular Location

Nucleus, nucleoplasm . Predominantly nuclear. Associated with telomeric heterochromatin regions.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.