Anti-HDAC8/Histone Deacetylase 8 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-HDAC8/Histone Deacetylase 8 Rabbit Monoclonal Antibody catalog # M01843. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human.

Specifications

Catalog number

M01843

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Histone deacetylase 8; HD8;3.5.1.98; HDAC8; HDACL1; CDA07

Gene Name

HDAC8

Gene ID

55869

UniProt

Q9BY41

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human HDAC8

Clonality

Monoclonal

Clone

Clone: HIO-8

Tissue Specificity

Weakly expressed in most tissues. Expressed at higher level in heart, brain, kidney and pancreas and also in liver, lung, placenta, prostate and kidney. .

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

Acetylation, Cardiovascular, Chromatin Modifying Enzymes, Class I, Epigenetics and Nuclear Signaling, Hypertrophy, Signaling Pathways, Stem Cells, Transcription

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

41758 MW

Observed Molecular Weight

50 kDa

Gene Name Synonym

Histone deacetylase 8

Subcellular Location

Nucleus. Cytoplasm. Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation.

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.