Anti-Hsp75 TRAP1 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Hsp75 TRAP1 Rabbit Monoclonal Antibody catalog # M02426-1. Tested in WB, IP applications. This antibody reacts with Human.

Specifications

Catalog number

M02426-1

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Heat shock protein 75 kDa, mitochondrial; HSP 75; TNFR-associated protein 1; Tumor necrosis factor type 1 receptor-associated protein; TRAP-1; TRAP1; HSP75

Gene Name

TRAP1

Gene ID

10131

UniProt

Q12931

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Hsp75

Clonality

Monoclonal

Clone

Clone: IBD-20

Tissue Specificity

Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is higly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. .

Applications

WB, IP

Field of Research

Apoptosis, Cancer, Cell Biology, Cell Death, Chaperones, Heat Shock Proteins, Metabolism, Metabolism Processes, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Protein Trafficking, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

80110 MW

Observed Molecular Weight

35 kDa, 39 kDa

Gene Name Synonym

Heat shock protein 75 kDa, mitochondrial

Subcellular Location

Mitochondrion . Mitochondrion inner membrane . Mitochondrion matrix .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.