Anti-EBP50 SLC9A3R1 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-EBP50 SLC9A3R1 Rabbit Monoclonal Antibody catalog # M02427. Tested in WB, IHC applications. This antibody reacts with Human, Rat.

Specifications

Catalog number

M02427

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Na (+) /H (+) exchange regulatory cofactor NHE-RF1; NHERF-1; Ezrin-radixin-moesin-binding phosphoprotein 50; EBP50; Regulatory cofactor of Na (+) /H (+) exchanger; Sodium-hydrogen exchanger regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1; SLC9A3R1; NHERF, NHERF1

Gene Name

SLC9A3R1

Gene ID

9368

UniProt

O14745

Host

Rabbit

Reactivity

Human, Rat

Immunogen

A synthesized peptide derived from human EBP50

Clonality

Monoclonal

Clone

Clone: IIH-19

Tissue Specificity

Detected in liver, kidney, pancreas, prostate, spleen, small intestine and placenta, in particular in the syncytiotrophoblast. .

Applications

WB, IHC

Field of Research

Actin Binding Proteins, Actin, etc., Adapters, Cancer, Cell Type Markers, Cytoskeleton, Cytoskeleton/ECM, Extracellular Matrix, Invasion/Microenvironment, Microfilaments, Signal Transduction, Tags & Cell Markers, Transmembrane

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity) . Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

38868 MW

Observed Molecular Weight

80 kDa

Gene Name Synonym

Na (+) /H (+) exchange regulatory cofactor NHE-RF1

Subcellular Location

Cytoplasm . Apical cell membrane . Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Translocates from the cytoplasm to the apical cell membrane in a PODXL-dependent manner. Colocalizes with CFTR at the midpiece of sperm tail (By similarity) . Colocalizes with actin in microvilli-rich apical regions of the syncytiotrophoblast. Found in microvilli, ruffling membrane and filopodia of HeLa cells. Present in lipid rafts of T- cells. .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.