Anti-FOXA2/Hnf3B Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-FOXA2/Hnf3B Rabbit Monoclonal Antibody catalog # M01032. Tested in WB, ICC/IF applications. This antibody reacts with Human, Rat.

Specifications

Catalog number

M01032

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; Forkhead box protein A2; Transcription factor 3B; TCF-3B; FOXA2; HNF3B, TCF3B

Gene Name

FOXA2

Gene ID

3170

UniProt

Q9Y261

Host

Rabbit

Reactivity

Human, Rat

Immunogen

A synthesized peptide derived from human FOXA2

Clonality

Monoclonal

Clone

Clone: AAAH-6

Tissue Specificity

Ubiquitous. .

Applications

WB, ICC, IF

Field of Research

Developmental Biology, Domain Families, Epigenetics and Nuclear Signaling, Forkhead Box, Lineage Markers, Lineage Specification, Metabolism, Obesity, Stem Cells, Transcription

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity) . In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

48306 MW

Observed Molecular Weight

120 kDa

Gene Name Synonym

Hepatocyte nuclear factor 3-beta

Subcellular Location

Nucleus . Cytoplasm . Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.