Anti-BNIP3 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-BNIP3 Rabbit Monoclonal Antibody catalog # M01469. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M01469

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; BNIP3; NIP3

Gene Name

BNIP3

Gene ID

664

UniProt

Q12983

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human BNIP3

Clonality

Monoclonal

Clone

Clone: AAEI-2

Tissue Specificity

Detected in the flagellum and head region of spermatozoa (at protein level) . .

Applications

WB, IHC, ICC, IF

Field of Research

Metabolism, Metabolism Processes, Microbiology, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Response To Hypoxia

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9) -induced cell death pathway. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

21541 MW

Observed Molecular Weight

314 kDa

Gene Name Synonym

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Subcellular Location

Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Coexpression with the EIB 19- kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.