Anti-NFAT2 NFATC1 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-NFAT2 NFATC1 Rabbit Monoclonal Antibody catalog # M00340. Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human.

Specifications

Catalog number

M00340

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Nuclear factor of activated T-cells, cytoplasmic 1; NF-ATc1; NFATc1; NFAT transcription complex cytosolic component; NF-ATc; NFATc; NFATC1; NFAT2, NFATC

Gene Name

NFATC1

Gene ID

4772

UniProt

O95644

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human NFAT2

Clonality

Monoclonal

Clone

Clone: ABDA-14

Tissue Specificity

Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T- cells (spleen) . Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T- cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum. .

Applications

WB, ICC, IF, Flow Cytometry

Field of Research

Adaptive Immunity, Cardiogenesis, Cardiovascular,2339, Epigenetics and Nuclear Signaling, Immunology, Non-CD, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, T Cells, Transcription, Transcription Factors/Regulators

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

101243 MW

Observed Molecular Weight

32 kDa

Gene Name Synonym

Nuclear factor of activated T-cells, cytoplasmic 1

Subcellular Location

Cytoplasm . Nucleus . Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription.

Protein Name

P2X purinoceptor 1

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.