Anti-FGFR4 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-FGFR4 Rabbit Monoclonal Antibody catalog # M00769. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M00769

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Fibroblast growth factor receptor 4; FGFR-4;2.7.10.1; CD334; FGFR4; JTK2, TKF

Gene Name

FGFR4

Gene ID

2264

UniProt

P22455

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human FGFR4

Clonality

Monoclonal

Clone

Clone: ABHA-6

Tissue Specificity

Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines. .

Applications

WB

Field of Research

Angiogenesis, Cancer, Cardiovascular, Cell Biology, Cell Type Marker, Cell Type Markers, Growth Factors, Growth Factors/Hormones, Neural Stem Cells, Neuroscience, Signal Transduction, Stem Cells, Surface Molecules, Tags & Cell Markers

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

87954 MW

Observed Molecular Weight

88 kDa

Gene Name Synonym

Fibroblast growth factor receptor 4

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.