Anti-CITED2 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-CITED2 Rabbit Monoclonal Antibody catalog # M02966. Tested in WB application. This antibody reacts with Human, Mouse.

Specifications

Catalog number

M02966

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Cbp/p300-interacting transactivator 2; MSG-related protein 1; MRG-1; P35srj; CITED2; MRG1

Gene Name

CITED2

Gene ID

10370

UniProt

Q99967

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A synthesized peptide derived from human CITED2

Clonality

Monoclonal

Clone

Clone: IEA-3

Tissue Specificity

Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.

Applications

WB

Field of Research

Cancer, Cancer Metabolism, Cardiovascular, Co-Activators/Co-Repressors, Epigenetics and Nuclear Signaling, Hypoxia, Invasion/Microenvironment, Metabolism, Metabolism Processes, Nuclear Receptors, Nuclear Signaling Pathways, Pathways and Processes, Response To Hypoxia

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM) . Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP) ; stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

28497 MW

Observed Molecular Weight

28 kDa

Gene Name Synonym

Cbp/p300-interacting transactivator 2

Subcellular Location

Nucleus . Colocalizes with EP300 in dot-like structures.

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.