Anti-ADAM17/Tace Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-ADAM17/Tace Rabbit Monoclonal Antibody catalog # M00604. Tested in WB, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M00604

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17;3.4.24.86; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD156b; ADAM17; CSVP, TACE

Gene Name

ADAM17

Gene ID

6868

UniProt

P78536

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human ADAM17

Clonality

Monoclonal

Clone

Clone: AOIO-1

Tissue Specificity

Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.

Applications

WB, ICC, IF, IP, Flow Cytometry

Field of Research

Adapters, Alzheimer's Disease, Cancer, Cancer Metabolism, Cell Biology, Extracellular Matrix, Invasion/Microenvironment, Metabolism, Metabolism Processes, Metalloprotease, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways and Processes, Proteolysis/Ubiquitin, Proteolytic Enzymes, Response To Hypoxia, Secreted, Signal Transduction, Signaling Pathways, Stem Cells, Transmembrane

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) . Plays a role in the proteolytic processing of ACE2. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

93021 MW

Observed Molecular Weight

32-42 kDa, 65 kDa, 75 kDa

Gene Name Synonym

Disintegrin and metalloproteinase domain-containing protein 17

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.