Anti-Cubilin CUBN Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Cubilin CUBN Rabbit Monoclonal Antibody catalog # M03670. Tested in WB, IHC applications. This antibody reacts with Human.

Specifications

Catalog number

M03670

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Cubilin;460 kDa receptor; Intestinal intrinsic factor receptor; Intrinsic factor-cobalamin receptor; Intrinsic factor-vitamin B12 receptor; CUBN; IFCR

Gene Name

CUBN

Gene ID

8029

UniProt

O60494

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Cubilin

Clonality

Monoclonal

Clone

Clone: GA-3

Tissue Specificity

Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.

Applications

WB, IHC

Field of Research

Cancer, Cancer Metabolism, Cofactors, Vitamins/Minerals, Endocrine Metabolism, Hormone Biosynthesis, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Signal Transduction, Vitamins/Minerals

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

398736 MW

Observed Molecular Weight

163 kDa

Gene Name Synonym

Cubilin

Subcellular Location

Apical cell membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Membrane, coated pit . Endosome . Lysosome membrane ; Peripheral membrane protein . Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells. .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.