Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody

Catalog number M01595

Price for M01595

Size / count 100 µL/Vial

About this product

Boster Bio Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody catalog # M01595. Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number: M01595
Size / count: 100 µL/Vial
Dry ice: No
Hazardous: No
Discontinued: No
Synonyms: E3 ubiquitin-protein ligase NEDD4-like;6.3.2.-; NEDD4.2; Nedd4-2; NEDD4L; KIAA0439, NEDL3
Gene Name: NEDD4L
Gene ID: 23327
UniProt: Q96PU5
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A synthesized peptide derived from human NEDD4-2
Clonality: Monoclonal
Clone: Clone: GOA-14
Tissue Specificity: Ubiquitously expressed, with highest levels in prostate, pancreas and kidney (PubMed:14615060, PubMed:15496141, PubMed:19664597) . Expressed in melanocytes (PubMed:23999003) . .
Applications: WB, IP
Field of Research: Cell Biology, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Proteasome / Ubiquitin, Proteolysis/Ubiquitin, Ubiquitin E3 Enzymes
Purification: Affinity-chromatography
Concentration: 0.5mg/ml
Form: Liquid
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then ly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046) . Plays a role in dendrite formation by melanocytes (PubMed:23999003) . .
Storage Conditions: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight: 111932 MW
Observed Molecular Weight: 130 kDa
Gene Name Synonym: E3 ubiquitin-protein ligase NEDD4-like
Subcellular Location: Cytoplasm . May be recruited to exosomes by NDFIP1.
Protein Name: Lysosome-associated membrane glycoprotein 2 (Lamp2)
Isotype: Rabbit IgG
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Frequently Asked Questions

What is the catalog number for Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody?

The catalog number for Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody is M01595.

What sizes are available for Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody?

Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody is available in the following size(s): 100 µL/Vial.

Is Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody in stock?

Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody?

The safety data sheet for Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody is available here: https://www.bosterbio.com/msds?sku=M01595.

What is Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody used for?

Boster Bio Anti-NEDD4-2 NEDD4L Rabbit Monoclonal Antibody catalog # M01595. Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat.

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.