Anti-Dysferlin Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Dysferlin Rabbit Monoclonal Antibody catalog # M01234. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

M01234

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Dysferlin; Dystrophy-associated fer-1-like protein; Fer-1-like protein 1; DYSF; FER1L1

Gene Name

DYSF

Gene ID

8291

UniProt

O75923

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A synthesized peptide derived from human Dysferlin

Clonality

Monoclonal

Clone

Clone: EGO-4

Tissue Specificity

Expressed in skeletal muscle, myoblast, myotube and in the syncytiotrophoblast (STB) of the placenta (at protein level) . Ubiquitous. Highly expressed in skeletal muscle. Also found in heart, brain, spleen, intestine, placenta and at lower levels in liver, lung, kidney and pancreas. .

Applications

WB, IHC, ICC, IF

Field of Research

Cell Biology

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Key calcium ion sensor involved in the Ca (2+) -triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

237295 MW

Observed Molecular Weight

280 kDa

Gene Name Synonym

Dysferlin

Subcellular Location

Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasmic vesicle membrane ; Single-pass type II membrane protein . Cell membrane. Colocalizes, during muscle differentiation, with BIN1 in the T-tubule system of myotubules and at the site of contact between two myotubes or a myoblast and a myotube. Wounding of myotubes led to its focal enrichment to the site of injury and to its relocalization in a Ca (2+) -dependent manner toward the plasma membrane. Colocalizes with AHNAK, AHNAK2 and PARVB at the sarcolemma of skeletal muscle. Detected on the apical plasma membrane of the syncytiotrophoblast. Reaches the plasmma membrane through a caveolin-independent mechanism. Retained by caveolin at the plasmma membrane (By similarity) . Colocalizes, during muscle differentiation, with CACNA1S in the T-tubule system of myotubules (By similarity) . Accumulates and colocalizes with fusion vesicles at the sarcolemma disruption sites (By similarity) . .

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.