Anti-Cortactin CTTN Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Cortactin CTTN Rabbit Monoclonal Antibody catalog # M01253. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M01253

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Src substrate cortactin; Amplaxin; Oncogene EMS1; CTTN; EMS1

Gene Name

CTTN

Gene ID

2017

UniProt

Q14247

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Cortactin

Clonality

Monoclonal

Clone

Clone: FAI-3

Tissue Specificity

The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons.

Applications

WB, IHC, ICC, IF, IP, Flow Cytometry

Field of Research

Signal Transduction, Cytoskeleton, Cytoskeleton/ECM, Actin Assembly, Actin Binding Proteins, Actin, etc., Microfilaments

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:21296879) . Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity) . Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (By similarity) . Plays a role in the invasiveness of cancer cells, and the formation of metastases (PubMed:16636290) . Plays a role in focal adhesion assembly and turnover (By similarity) . In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P) -mediated endothelial cell (EC) barrier enhancement (PubMed:20861316) . Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782) . Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity) . Required for stabilization of KCNH1 channels at the cell membrane (PubMed:23144454) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

61586 MW

Observed Molecular Weight

85 kDa

Gene Name Synonym

Src substrate cortactin

Subcellular Location

Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Cell projection, ruffle. Cell projection, dendrite . Cell projection . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, podosome . Cell junction . Cell junction, focal adhesion . Membrane, clathrin-coated pit . Cell projection, dendritic spine . Cytoplasm, cell cortex . Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity) . Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity) . In the presence of CTTNBP2, localizes at the cell cortex (By similarity) . In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity) . Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity) . .

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.