Anti-Human IgM IGHM Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Human IgM IGHM Rabbit Monoclonal Antibody catalog # M07469-1. Tested in WB, IHC, IP applications. This antibody reacts with Human.

Specifications

Catalog number

M07469-1

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Ig mu chain C region; IGHM

Gene Name

IGHM

Gene ID

3507

UniProt

P01871

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Human IgM

Clonality

Monoclonal

Clone

Clone: AOCG-9

Tissue Specificity

Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

Applications

WB, IHC, IP

Field of Research

RNA Polymerase, Transcription

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

49307 MW

Observed Molecular Weight

80 kDa

Gene Name Synonym

Ig mu chain C region

Subcellular Location

Isoform 1: Secreted. During differentiation, B-lymphocytes switch from expression of membrane- bound IgM to secretion of IgM.

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.