Anti-Claudin 1 CLDN1 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Claudin 1 CLDN1 Rabbit Monoclonal Antibody catalog # M01585. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M01585

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Claudin-1; Senescence-associated epithelial membrane protein; CLDN1; CLD1, SEMP1; UNQ481/PRO944

Gene Name

CLDN1

Gene ID

9076

UniProt

O95832

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Claudin 1

Clonality

Monoclonal

Clone

Clone: ABEH-3

Tissue Specificity

Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. .

Applications

WB

Field of Research

Cell Adhesion, Cytoskeleton/ECM, Signal Transduction, Tight Junctions

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an in effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

22744 MW

Observed Molecular Weight

23 kDa

Gene Name Synonym

Claudin-1

Subcellular Location

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.