Anti-PGC1 alpha PPARGC1A Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-PGC1 alpha PPARGC1A Rabbit Monoclonal Antibody catalog # M00236. Tested in WB application. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M00236

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; Ligand effect modulator 6; PPARGC1A; LEM6, PGC1, PGC1A, PPARGC1

Gene Name

PPARGC1A

Gene ID

10891

UniProt

Q9UBK2

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human PGC1 alpha

Clonality

Monoclonal

Clone

Clone: AOBC-16

Tissue Specificity

Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects. .

Applications

WB

Field of Research

Diabetes-associated, Epigenetics and Nuclear Signaling, Fatty Acid Oxidation, Fatty Acids, Heart Disease, Lipid and Lipoprotein Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Mitochondrial Metabolism, Nuclear Receptors, Nuclear Signaling Pathways, Nucleotide Metabolism, Obesity, Pathways and Processes, Redox Metabolism, Transcription

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

91027 MW

Observed Molecular Weight

100-110 kDa

Gene Name Synonym

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Subcellular Location

Isoform 1: Nucleus. Nucleus, PML body.

Protein Name

P2X purinoceptor 1

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.