Anti-Podoplanin PDPN Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Podoplanin PDPN Rabbit Monoclonal Antibody catalog # M01124-2. Tested in WB, IHC applications. This antibody reacts with Human.

Specifications

Catalog number

M01124-2

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Podoplanin; Aggrus; Glycoprotein 36; Gp36; PA2.26 antigen; T1-alpha; T1A; PDPN ; GP36 ; PSEC0003, PSEC0025

Gene Name

PDPN

Gene ID

10630

UniProt

Q86YL7

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Podoplanin

Clonality

Monoclonal

Clone

Clone: AAHB-16

Tissue Specificity

Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas. .

Applications

WB, IHC

Field of Research

Angiogenesis, Cardiovascular, Cell Type Markers, Tags & Cell Markers, Vasculature

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

16698 MW

Observed Molecular Weight

80 kDa

Gene Name Synonym

Podoplanin

Subcellular Location

Membrane ; Single-pass type I membrane protein . Cell projection, filopodium membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium membrane ; Single-pass type I membrane protein . Cell projection, microvillus membrane ; Single-pass type I membrane protein . Cell projection, ruffle membrane ; Single-pass type I membrane protein . Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles. .

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.