Anti-VE-Cadherin Cdh5-Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-VE-Cadherin Cdh5-Rabbit Monoclonal Antibody catalog # M02632. Tested in WB, ICC/IF, IP applications. This antibody reacts with Mouse.

Specifications

Catalog number

M02632

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Cadherin-5; Vascular endothelial cadherin; VE-cadherin; CD144; Cdh5

Gene Name

Cdh5

Gene ID

12562

UniProt

P55284

Host

Rabbit

Reactivity

Mouse

Immunogen

A synthesized peptide derived from mouse VE Cadherin

Clonality

Monoclonal

Clone

Clone: IIC-3

Tissue Specificity

Keratinocytes of epidermis and other stratified squamous epithelia.

Applications

WB, ICC, IF, IP

Field of Research

Atherosclerosis, Cadherins, Cancer, Cardiovascular, Cell Adhesion, Cell Adhesion Molecules, Cytoskeleton/ECM, Invasion/Microenvironment, Signal Transduction, Vascular Inflammation, Vasculature

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

87903 MW

Observed Molecular Weight

45 kDa

Gene Name Synonym

Cadherin-5

Subcellular Location

Cell junction . Cell membrane ; Single-pass type I membrane protein . Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions (By similarity) . .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.