Anti-Lipocalin-2 LCN2 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Lipocalin-2 LCN2 Rabbit Monoclonal Antibody catalog # M00452. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Specifications

Catalog number

M00452

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Neutrophil gelatinase-associated lipocalin; NGAL;25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; Siderocalin LCN2; p25; LCN2; HNL, NGAL

Gene Name

LCN2

Gene ID

3934

UniProt

P80188

Host

Rabbit

Reactivity

Human

Immunogen

Human Lipocalin-2

Clonality

Monoclonal

Clone

Clone: AABA-12

Tissue Specificity

Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. .

Applications

WB, IHC, ICC, IF

Field of Research

Immunoglobulins, Immunology

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

22588 MW

Observed Molecular Weight

73 kDa

Gene Name Synonym

Neutrophil gelatinase-associated lipocalin

Subcellular Location

Secreted . Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.