Anti-MEF2A+MEF2C Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-MEF2A+MEF2C Rabbit Monoclonal Antibody catalog # M01131. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M01131

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Myocyte-specific enhancer factor 2C; MEF2C

Gene Name

MEF2C

Gene ID

4208

UniProt

Q06413/Q02078

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human MEF2A+MEF2C

Clonality

Monoclonal

Clone

Clone: ABGA-13

Tissue Specificity

Expressed in brain and skeletal muscle. .

Applications

WB, IHC, ICC, IF, Flow Cytometry

Field of Research

Calcium Signaling, Calmodulin Pathway, Cardiogenesis, Cardiovascular, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Hypertrophy, Mesenchymal Stem Cells, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction, Signaling Pathway, Stem Cells, Transcription, Transcription Factors, Transcription Factors/Regulators

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity) . Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

51221 MW

Observed Molecular Weight

52 kDa

Gene Name Synonym

Myocyte-specific enhancer factor 2C

Subcellular Location

Nucleus.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.