Anti-Angiopoietin 1 ANGPT1 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Angiopoietin 1 ANGPT1 Rabbit Monoclonal Antibody catalog # M00853. Tested in WB application. This antibody reacts with Human, Rat.

Specifications

Catalog number

M00853

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Angiopoietin-1; ANG-1; ANGPT1; KIAA0003

Gene Name

ANGPT1

Gene ID

284

UniProt

Q15389

Host

Rabbit

Reactivity

Human, Rat

Immunogen

A synthesized peptide derived from human Angiopoietin 1

Clonality

Monoclonal

Clone

Clone: FGC-1

Tissue Specificity

KMT4 / Dot1L Antibody detects endogenous levels of total KMT4 / Dot1L

Applications

WB

Field of Research

Angiogenesis, Cardiovascular, Growth Factors

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

57513 MW

Observed Molecular Weight

70 kDa

Gene Name Synonym

Angiopoietin-1

Subcellular Location

Secreted.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.