Anti-Myosin Light Chain 2 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Myosin Light Chain 2 Rabbit Monoclonal Antibody catalog # M03215. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M03215

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform ; MLC-2 ; MLC-2v; Cardiac myosin light chain 2 ; Myosin light chain 2, slow skeletal/ventricular muscle isoform ; MLC-2s/v ; Ventricular myosin light chain 2 ; MYL2 ; MLC2

Gene Name

MYL2

Gene ID

4633

UniProt

P10916

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Myosin Light Chain 2

Clonality

Monoclonal

Clone

Clone: FHO-13

Tissue Specificity

In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain. .

Applications

WB, IHC, IP

Field of Research

Motor Proteins, Myosin, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Contractile protein that plays a role in heart development and function (By similarity) . Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) . During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

18789 MW

Observed Molecular Weight

29 kDa

Gene Name Synonym

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

Subcellular Location

Cytoplasm, myofibril, sarcomere, A band .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.