Anti-TGF beta Receptor II TGFBR2 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-TGF beta Receptor II TGFBR2 Rabbit Monoclonal Antibody catalog # M00759. Tested in WB application. This antibody reacts with Human.

Specifications

Catalog number

M00759

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

TGF-beta receptor type-2; TGFR-2;2.7.11.30; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II; TGFBR2

Gene Name

TGFBR2

Gene ID

7048

UniProt

P37173

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human TGF beta Receptor II

Clonality

Monoclonal

Clone

Clone: ABFE-20

Tissue Specificity

Expressed in fetal brain and in adult brain, heart, small intestine and colon.

Applications

WB

Field of Research

Nuclear Signaling, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Signaling Pathway, Signaling Pathways, Stem Cells, Surface Molecules, TGF Beta

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non- canonical, SMAD-independent TGF-beta signaling pathways. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

64568 MW

Observed Molecular Weight

20 kDa

Gene Name Synonym

TGF-beta receptor type-2

Subcellular Location

Cell membrane ; Single-pass type I membrane protein .

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.