Anti-Cytokeratin 5 (C-term) KRT5 Rabbit Monoclonal Antibody

About this product

KRT5 Rabbit Monoclonal Antibody

Specifications

Catalog number

M00398-2

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Keratin, type II cytoskeletal 5;58 kDa cytokeratin; Cytokeratin-5; CK-5; Keratin-5; K5; Type-II keratin Kb5; KRT5

Gene Name

KRT5

Gene ID

3852

UniProt

P13647

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Cytokeratin 5 (C-term)

Clonality

Monoclonal

Clone

Clone: AGD-11

Tissue Specificity

Released primarily from activated T lymphocytes.

Applications

WB, IHC, ICC, IF

Field of Research

Class I, Cytoskeleton, Cytoskeleton/ECM, Intermediate Filaments, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53- mediated transcriptional activation. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

62378 MW

Observed Molecular Weight

43 kDa

Gene Name Synonym

Keratin, type II cytoskeletal 5

Subcellular Location

Nucleus. Chromosome, centromere, kinetochore. Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. H4K20me2 is required for efficient localization to double strand breaks and removal of proteins that have a high affinity for H4K20me2 such as L3MBTL1 and KDM4A is needed.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.