Anti-Somatostatin Receptor 2 SSTR2 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Somatostatin Receptor 2 SSTR2 Rabbit Monoclonal Antibody catalog # M01689. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M01689

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Somatostatin receptor type 2; SS-2-R; SS2-R; SS2R; SRIF-1; SSTR2

Gene Name

SSTR2

Gene ID

6752

UniProt

P30874

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Somatostatin Receptor 2

Clonality

Monoclonal

Clone

Clone: CIF-19

Tissue Specificity

Expressed in both pancreatic alpha- and beta- cells (at protein level) . Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood. .

Applications

WB, IHC, IP

Field of Research

Cancer, Cancer Metabolism, Endocrine Metabolism, Hormone Biosynthesis, Metabolic Signaling Pathway, Metabolism, More Gpcr, Neurology Process, Neuropeptides, Neuroscience, Neurotransmission, Neurotransmitter, Pathways and Processes, Receptors / Channels

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

41333 MW

Observed Molecular Weight

120 kDa

Gene Name Synonym

Somatostatin receptor type 2

Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasm. Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.