Anti-Transferrin Receptor (CD71) TFRC Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Transferrin Receptor (CD71) TFRC Rabbit Monoclonal Antibody catalog # M00591-1. Tested in WB, IHC, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M00591-1

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Transferrin receptor protein 1; TR; TfR; TfR1; Trfr; T9; p90; CD71; Transferrin receptor protein 1, serum form; sTfR; TFRC

Gene Name

TFRC

Gene ID

7037

UniProt

P02786

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human TFR

Clonality

Monoclonal

Clone

Clone: AOAA-20

Tissue Specificity

Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Applications

WB, IHC, IP, Flow Cytometry

Field of Research

Pathways and Processes, Response To Hypoxia, Serum Proteins, Stem Cells, Surface Molecules, T Lymphocytic Lineage

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

84871 MW

Observed Molecular Weight

95 kDa

Gene Name Synonym

Transferrin receptor protein 1

Subcellular Location

Cell membrane ; Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.