Anti-Retinoic Acid Receptor alpha RARA Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Retinoic Acid Receptor alpha RARA Rabbit Monoclonal Antibody catalog # M00392. Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

M00392

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Retinoic acid receptor alpha; RAR-alpha; Nuclear receptor subfamily 1 group B member 1; RARA; NR1B1

Gene Name

RARA

Gene ID

5914

UniProt

P10276

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A synthesized peptide derived from human Retinoic Acid Receptor alpha

Clonality

Monoclonal

Clone

Clone: GBC-18

Tissue Specificity

Expressed in various lymphoid tissues and activated B- and T-lymphocytes, strongly up-regulated in B-cells infected with Epstein-Barr virus and T-cells infected with herpesvirus 6 or 7.

Applications

WB, Flow Cytometry

Field of Research

Cancer, Cancer Metabolism, Domain Families, Epigenetics and Nuclear Signaling, Metabolism, Metabolism Processes, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling Pathways, Pathways and Processes, Response To Hypoxia, Signal Transduction, Signaling Pathway, Transcription, Zinc Finger

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity) . Regulates expression of target genes in a ligand- dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

50771 MW

Observed Molecular Weight

43 kDa

Gene Name Synonym

Retinoic acid receptor alpha

Subcellular Location

Nucleus. Cytoplasm. Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation.

Protein Name

T-cell surface glycoprotein CD4

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.