Anti-Stromal interaction molecule 1 STIM1 Rabbit Monoclonal Antibody

About this product

Boster Bio Anti-Stromal interaction molecule 1 STIM1 Rabbit Monoclonal Antibody catalog # M00312. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.

Specifications

Catalog number

M00312

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Stromal interaction molecule 1; STIM1; GOK

Gene Name

STIM1

Gene ID

6786

UniProt

Q13586

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthesized peptide derived from human Stromal interaction molecule 1

Clonality

Monoclonal

Clone

Clone: HEC-19

Tissue Specificity

Ubiquitously expressed in various human primary cells and tumor cell lines. .

Applications

WB, IHC, IP

Field of Research

Calcium Channels, Calcium Signaling, Cancer, Metabolism, Plasma Membrane, Signal Transduction, Signaling Pathway

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Plays a role in mediating store-operated Ca (2+) entry (SOCE), a Ca (2+) influx following depletion of intracellular Ca (2+) stores. Acts as Ca (2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca (2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca (2+) release-activated Ca (2+) (CRAC) channel subunit, TMEM142A/ORAI1. Involved in enamel formation. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

77423 MW

Observed Molecular Weight

85 kDa

Gene Name Synonym

Stromal interaction molecule 1

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules.

Protein Name

P2X purinoceptor 1

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.