Anti-FRS2 Monoclonal Antibody

About this product

Boster Bio Anti-FRS2 Monoclonal Antibody catalog # M02798. Tested in WB, IP, Flow Cytometry applications. This antibody reacts with Human.

Specifications

Catalog number

M02798

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Histone-lysine N-methyltransferase SETD7;2.1.1.43; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9; SETD7; KIAA1717, KMT7, SET7, SET9

Gene Name

FRS2

Gene ID

10818

UniProt

Q8WU20

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human FRS2 Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Clonality

Monoclonal

Clone

Clone: ACOG-6

Tissue Specificity

Widely expressed. Expressed in pancreatic islets.

Applications

WB, IP, Flow Cytometry

Field of Research

Growth Factors/Hormones, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

40721 MW

Observed Molecular Weight

140 kDa

Gene Name Synonym

Histone-lysine N-methyltransferase SETD7

Subcellular Location

Nucleus. Chromosome .

Protein Name

T-cell surface glycoprotein CD3 zeta chain

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.