- Catalog number
- M00934
- Size / count
- 100 µL/Vial
- Dry ice
- No
- Hazardous
- No
- Discontinued
- No
- Synonyms
- Mitogen-activated protein kinase kinase kinase 5;2.7.11.25; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5; MAP3K5; ASK1, MAPKKK5, MEKK5
- Gene Name
- BST2
- Gene ID
- 684
- UniProt
- Q10589
- Host
- Rabbit
- Reactivity
- Human
- Immunogen
- A synthesized peptide derived from human BST2 May be involved in the sorting of secreted proteins (By similarity) . May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of retrovirus from the cell surface.
- Clonality
- Monoclonal
- Clone
- Clone: ACCD-2
- Tissue Specificity
- Abundantly expressed in heart and pancreas.
- Applications
- WB, IHC, Flow Cytometry
- Field of Research
- Adaptive Immunity, Antiviral Signaling, B Cells, Cardiovascular, Cell Type Markers, Epigenetics and Nuclear Signaling, Hematopoietic Progenitors, Immune System Diseases, Immunology, NFKB Pathway, Non-CD, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Stem Cells, Surface Molecules, Tags & Cell Markers
- Purification
- Affinity-chromatography
- Concentration
- 0.5mg/ml
- Form
- Liquid
- Function
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS) . Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs) . Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1) . .
- Storage Conditions
- Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
- Calculated Molecular Weight
- 154537 MW
- Observed Molecular Weight
- 120-150 kDa
- Gene Name Synonym
- Mitogen-activated protein kinase kinase kinase 5
- Subcellular Location
- Cytoplasm. Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.
- Protein Name
- Glycogen synthase kinase-3 beta (gsk3b)
- Isotype
- Rabbit IgG
- Contents
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
