Anti-PHOX2B Monoclonal Antibody

About this product

Boster Bio Anti-PHOX2B Monoclonal Antibody catalog # M02221. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse.

Specifications

Catalog number

M02221

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

CD276 antigen;4Ig-B7-H3; B7 homolog 3; B7-H3; Costimulatory molecule; CD276; CD276; B7H3; PSEC0249, UNQ309/PRO352

Gene Name

PHOX2B

Gene ID

8929

UniProt

Q99453

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

A synthesized peptide derived from human PHOX2B Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element.

Clonality

Monoclonal

Clone

Clone: AEFG-16

Tissue Specificity

Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta. .

Applications

WB, IHC, ICC, IF

Field of Research

Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Neural Signal Transduction, Neurogenesis, Neurology Process, Neuroscience, Transcription

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

57235 MW

Observed Molecular Weight

90 kDa

Gene Name Synonym

CD276 antigen

Subcellular Location

Membrane ; Single-pass type I membrane protein .

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.