Anti-Parathyroid Hormone Receptor 1 Monoclonal Antibody

About this product

Boster Bio Anti-Parathyroid Hormone Receptor 1 Monoclonal Antibody catalog # M01588. Tested in WB, IP applications. This antibody reacts with Human.

Specifications

Catalog number

M01588

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Claudin-1; Senescence-associated epithelial membrane protein; CLDN1; CLD1, SEMP1; UNQ481/PRO944

Gene Name

PTH1R

Gene ID

5745

UniProt

Q03431

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human Parathyroid Hormone Receptor 1 Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.

Clonality

Monoclonal

Clone

Clone: AEHO-16

Tissue Specificity

Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. .

Applications

WB, IP

Field of Research

Endocrine System, Growth Factors/Hormones, Neuroscience, Signal Transduction

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an in effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (PubMed:23407391) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

22744 MW

Observed Molecular Weight

47 kDa

Gene Name Synonym

Claudin-1

Subcellular Location

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

Protein Name

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.