Anti-KAT13A / SRC1 Monoclonal Antibody

About this product

Boster Bio Anti-KAT13A / SRC1 Monoclonal Antibody catalog # M00856. Tested in WB, IHC, IP applications. This antibody reacts with Human.

Specifications

Catalog number

M00856

Size / count

100 µL/Vial

Dry ice

No

Hazardous

No

Discontinued

No

Synonyms

Angiopoietin-1; ANG-1; ANGPT1; KIAA0003

Gene Name

NCOA1

Gene ID

8648

UniProt

Q15788

Host

Rabbit

Reactivity

Human

Immunogen

A synthesized peptide derived from human KAT13A / SRC1 Nuclear receptor coactivator that ly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs) .

Clonality

Monoclonal

Clone

Clone: AEHD-14

Tissue Specificity

KMT4 / Dot1L Antibody detects endogenous levels of total KMT4 / Dot1L

Applications

WB, IHC, IP

Field of Research

Acetylation, Cancer, Cancer Metabolism,2339, Chromatin Modifying Enzymes, Co-Activators/Co-Repressors, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling Pathways, Oncoproteins, Oncoproteins/Suppressors, Pathways and Processes, Signal Transduction, Signaling Pathway, Transcription

Purification

Affinity-chromatography

Concentration

0.5mg/ml

Form

Liquid

Function

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

57513 MW

Observed Molecular Weight

157 kDa

Gene Name Synonym

Angiopoietin-1

Subcellular Location

Secreted.

Protein Name

Glycogen synthase kinase-3 beta (gsk3b)

Isotype

Rabbit IgG

Contents

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.